modafinil dosage - An Overview
modafinil dosage - An Overview
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No precise dose adjustment proposed when tofacitinib coadministered with strong CYP2C19 inhibitors; lessen tofacitinib dose if coadministered with both moderate CYP3A4 and potent CYP2C19 inhibitors .
Monitor Intently (1)modafinil improves amounts of eluxadoline by influencing hepatic enzyme CYP2C19 metabolism. Use Warning/Keep an eye on. As being a precautionary measure as a consequence of incomplete info on the metabolism of eluxadoline, use caution when coadministered with potent CYP2C19 inhibitors.
modafinil will increase the stage or impact of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Contraindicated. Solid or average CYP2C19 inhibitors may possibly raise mavacamten systemic exposure, causing coronary heart failure due to systolic dysfunction.
When a doctor prescribes modafinil, they provide comprehensive Guidance on dosages for his or her unique use.
The above information and facts is provided more information for typical informational and educational purposes only. Unique ideas may range and formulary data adjustments. Call the applicable plan company for by far the most present information and facts.
Metabolism: Modafinil undergoes hepatic metabolism by using several pathways, such as CYP3A4. 80% with the dose is recovered within the urine in the form of metabolites.
PROVIGIL is contraindicated in patients with recognised hypersensitivity to modafinil or armodafinil or its inactive elements [see WARNINGS AND PRECAUTIONS].
Medicine that require prior authorization. This restriction calls for that specific scientific requirements be fulfilled prior to the approval of your prescription.
Any dose that is certainly 50 mg or fewer is considered a microdose— this means the dose is below the therapeutic threshold.
Possibility of skin reactions (eg SJS, toxic necrolysis, and drug rash with eosinophilia and systemic signs and symptoms); discontinue if rash or other hypersensitivity reactions come about
modafinil will lower the extent or effect of copyright topical by affecting hepatic enzyme CYP2B6 metabolism. Slight/Importance Unknown.
Remember, maintain this and all other medicines out on the access of children, in no way share your medicines with Other folks, and use Provigil just for the indicator prescribed.
Provigil has not been adequately studied in pregnant Ladies and it is not known whether it is excreted in breast milk. Consult your physician right before breastfeeding. Supplemental Facts